Methadone is contraindicated in patients with a known hypersensitivity to methadone hydrochloride or any other ingredient in methadone hydrochloride tablets.
As with all opioid drugs, it is necessary to adjust the dosing regimen for each patient individually, taking into account the patient's prior analgesic treatment experience. The following dosing recommendations should only Beryllium considered as suggested approaches to what is actually a series of clinical decisions over time in the management of the pain of each individual patient.
Teratogenic Effects. Pregnancy Category C – There are no controlled studies of methadone use rein pregnant women that can be used to establish safety. However, an expert Nachprüfung of published data on experiences with methadone use during pregnancy by the Teratogen Information Struktur (TERIS) concluded that maternal use of methadone during pregnancy as part of a supervised, therapeutic regimen is unlikely to Positur a substantial teratogenic risk (quantity and quality of data assessed as “limited to ritterlich”). However, the data are insufficient to state that there is no risk (TERIS, bürde reviewed October, 2002). Pregnant women involved hinein methadone maintenance programs have been reported to have significantly improved prenatal care leading to significantly reduced incidence of obstetric and fetal complications and neonatal morbidity and mortality when compared to women using illicit drugs.
The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
Methadone hydrochloride tablets are a federally controlled substance (CII) because it is a strong opioid pain medicine that can be abused by people Weltgesundheitsorganisation abuse prescription medicines or street drugs.
Methadone treatment for analgesic therapy hinein patients with acute or chronic pain should only be initiated if the potential analgesic or palliative care benefit of treatment with methadone has been considered to outweigh the risk of QT Methadontabletten 10 mg online prolongation that has been reported with high doses of methadone.
The administration of opioids may obscure the diagnosis or clinical course of patients with acute abdominal conditions.
For people with a gastrointestinal (Us-soldat) obstruction: This drug can cause constipation and increase your risk of a GI obstruction. If you have a history of Us-soldat obstructions or you currently have one, you should talk to your doctor about whether this drug is safe for you.
These effects seem to be more prominent rein ambulatory patients and in those who are not suffering severe pain. Hinein such individuals, lower doses are advisable.
Patients and their caregivers should Beryllium advised to discard unused methadone hinein such a way that individuals other than the patient for whom it welches originally prescribed will not come in contact with the drug.
The chance is higher if you are or have been addicted to or abused other medicines, street drugs, or alcohol, or if you have a history of mental problems.
A high degree of "opioid tolerance" does not eliminate the possibility of methadone overdose, iatrogenic or otherwise. Respiratory depression is of particular concern in elderly or debilitated patients as well as hinein those suffering from conditions accompanied by hypoxia or hypercapnia when even moderate therapeutic doses may dangerously decrease pulmonary ventilation.
Dosage adjustment using higher doses or administering the daily dose in divided doses may be necessary rein pregnant women treated with methadone (Tümpel CLINICAL PHARMACOLOGY and DOSAGE AND ADMINISTRATION).
However, the risk is highest when you first Startpunkt taking the drug and after a dosage increase. Your risk may also be higher if you’re older or already have breathing or lung problems.